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Keep an eye on Intently (one)pentobarbital will decrease the level or influence of fentanyl transdermal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep an eye on Closely. Coadministration of fentanyl with CYP3A4 inducers may lead to the reduce in fentanyl plasma concentrations, deficiency of efficacy or, maybe, advance